Crohn's Disease: Retrospective Study In Algerian Patients

Background: Inflammatory disease of Crohn affects the entire digestive tract, with extra-intestinal manifestations and immune disorders.
 Objectives: This work aims to represent histopathological aspects Crohn‘s establishment pathogenic bacteria as causal agents.
 Methodology: The were studied on a colonic resection specimen intestinal biopsies colorations topographic staining. Pathogenic responsible for have also been isolated identified. study is continued establish correlation between exposure infections by unusual bacteria, particularly pathogens (Salmonella, Shigella, Streptococcus pyogenes, Klebsiella).
 Results : macroscopic appearance presented transmural involvement can be complicated abscesses fistulas, microscopic indicated infiltrate inflammatory cells (lymphocytes, plasma cells) lymphoid follicles after staining.
 Crohn’s an idiopathic disease, it assumed that deregulation system due infectious agent in genetically predisposed people.
 In our work, we microbiota intestine stool patients which found certain including Proteus mirabilis predominance E. coli. Other like Salmonella spp., Shigella Klebsiella spp. pyogenes. Two cases tested positive Ziehl Neelsen stain represented Mycobacterium avium paratuberculosis.
 Conclusion: aspect CD better visualized identified surgical specimens than endoscopic biopsies, helps monitor evolution must accompanied clinical, serological radiological exploration.